If research into Rapamycin, Metformin or their combination shows promising longevity benefits, by December 31, 2041, in the context of a large-scale population based observational studies or randomised controlled trials in healthy individuals aged 50 and older, will the group not using either Metformin or Rapamycin while still receiving a stand healthcare will show median lifespan or rate of biological ageing that is not significantly lower than the groups using either or both drugs.

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